Vegetables are an important food group to include in any healthy diet, and a diabetes diet is no exception. Treatment for type 1 diabetes includes taking insulin and possibly another injectable medicine; making wise food choices; being physically active; taking aspirin daily, for some; and controlling blood pressure and cholesterol. A lot of people with Type 1 diabetes are very upset with this for the very understandable reason that it is impossible to go insulin if you have Type 1 diabetes unless you get an experimental pancreas or beta cell transplant–and even those are iffy. This trial is called the “Azithromycin Insulin Diet Intervention Trial in Type 1 Diabetes (AIDIT)” to include all three of the interventions being used. I’m not particularly interested in new types of insulin, and most of these were standard “we hope it is a little better, and a little more expensive, than you get now” type insulin. Between 1988 and 2000, of 160,000 people treated for a fractured ankle, 5.71% also had type 2 diabetes. Several people have emailed me wondering why I didn’t comment on the item that has been in the news about a newly discovered hormone that supposedly; causes the regrowth of the pancreas.
However, this was a huge study of a SGLT2 drug in type-2 diabetes, so I won’t comment. T1D. However, I’m summarizing all of them here, to give everyone a feel for all the types of type-1 diabetes research underway, and because some people might be interested in some of the non-cure research. If they are perishable, give them to someone who can use them without compromising their health. This trial will enroll people between 6 and 16 years old, who have been diagnosed within the last 10 days, so only “just diagnosed” people can participate. One way that I find new studies which are aimed at curing type-1 diabetes, is by searching the FDA’s Clinical Trial Registry. Blood sugar control is particularly important in pregnancy because a fetus that is exposed to continually high blood sugars will experience significant changes in the way that its genes express which will affect its blood sugar metabolism for the rest of its life. In this type, your pancreas does not make enough insulin and freestyle libre adhesive you have to take insulin injections for the rest of your life. According to the CDC, “people who have obesity, compared to those with a healthy weight, are at increased risk for many serious diseases and health conditions.” They are more likely to die from all-causes of death, more likely to have high blood pressure, high LDL and low HDL cholesterol, or high levels of triglycerides (Dyslipidemia), coronary heart disease, stroke, gallbladder disease, osteoarthritis (a breakdown of cartilage and bone within a joint), sleep apnea and breathing problems, many types of cancer, mental illness, body pain, and in general, a lower quality of life.
High blood sugar may also cause headaches, increased thirst, and tiredness that can interfere with falling asleep. The whole presentation was well done, and well worth viewing, but if you just want some quick data: fast forward to slide 25 (usual care) and then compare it to 26 (AP); this is for one selected patient, but you can see the huge improvement. One patient dropped out of this study because he was not able to trust the device enough to participate in the study. Production of a fully integrated device (prototype already made via private donations). Dr. Russell said that the FDA had indicated that this device and long term glucagon use, could be approved based on a single pivotal trial of 450 patients for 6 months, with a 6 month extension for 100 of the patients. These researchers are now testing 24 hour use of the device. They are testing it for safety in newly diagnosed type-1 diabetics.
These researchers are testing a type-1 diabetes vaccine made from part of an insulin molecule. Called “Insulin 287”, it is a background insulin, similar to Lantus, Levemir, or Tresiba, but designed to be taken once a week. It is studying TMEM219 also called “TMEM219 death factor” and “Transmembrane Protein 219”. This protein is clearly involved in the death of beta cells, and is sensitive to insulin-related proteins. Today’s study is NOT news. I’ve divided this posting into four areas: news on human trials aimed at a cure, artificial pancreas research, high buzz research, and other research I found interesting. AP did better than non-AP in terms of time in target, with less time in both high and low BG. AP did better than non-AP in terms of average BG, and no worse for lows. The BG improvements seen in these younger kids was better than seen in adults or in camp kids. AP also did better on A1c. But let’s get one thing clear: Nothing in the ACCORD study suggests that lowering A1c is harmful when it is done by cutting back on carbohydrate intake, avoiding the cardiotoxic TZD drugs Avandia and Actos that were heavily used in ACCORD, and using insulin only after being given a good explanation about how it works that allows you to adjust and tailor your doses based on what you see with your meter.
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